The objective of this study was to describe disease severity and outcomes of SARS-CoV-2 infections in pregnancy across Washington State including pregnancy complications and outcomes, hospitalization, and case fatality. Findings suggest that COVID-19 hospitalization and case fatality rates in pregnant patients were significantly higher compared to similarly aged adults in Washington State. This data indicates that pregnant patients are at risk for severe or critical disease and mortality compared to non-pregnant adults, as well as preterm birth.
Lokken EM, Walker CL, Delaney S, Kachikis A, Kretzer NM, Erickson A, Resnick R, Vanderhoeven J, Hwang JK, Barnhart N, Rah J, McCartney SA, Ma KK, Huebner EM, Thomas C, Sheng JS, Paek BW, Retzlaff K, Kline CR, Munson J, Blain M, LaCourse SM, Deutsch G, Adams Waldorf KM. Clinical characteristics of 46 pregnant women with a severe acute respiratory syndrome coronavirus 2 infection in Washington State. Am J Obstet Gynecol. 2020 Dec;223(6):911.e1-911.e14. doi: 10.1016/j.ajog.2020.05.031. Epub 2020 May 19. PMID: 32439389
Huntley BJF, Huntley ES, Di Mascio D, Chen T, Berghella V, Chauhan SP. Rates of Maternal and Perinatal Mortality and Vertical Transmission in Pregnancies Complicated by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Co-V-2) Infection: A Systematic Review. Obstet Gynecol. 2020 Aug;136(2):303-312. doi: 10.1097/AOG.0000000000004010.
Khoury R, Bernstein PS, Debolt C, Stone J, Sutton DM, Simpson LL, Limaye MA, Roman AS, Fazzari M, Penfield CA, Ferrara L, Lambert C, Nathan L, Wright R, Bianco A, Wagner B, Goffman D, Gyamfi-Bannerman C, Schweizer WE, Avila K, Khaksari B, Proehl M, Heitor F, Monro J, Keefe DL, D'Alton ME, Brodman M, Makhija SK, Dolan SM. Characteristics and Outcomes of 241 Births to Women With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection at Five New York City Medical Centers. Obstet Gynecol. 2020 Aug;136(2):273-282. doi: 10.1097/AOG.0000000000004025. PMID: 32555034