Protocol repository

In alignment with CERCLE’s steadfast commitment to transparency and upon obtaining the requisite permissions from investigators, we have been disseminating study materials specifically tailored to COVID-19 clinical research. This encompasses protocols, participant information sheets, informed consent forms, case report forms, standard operating procedures, and various other essential documents. As we continue to evolve, we aim to extend this initiative by incorporating and sharing materials pertinent to infectious diseases of epidemic and pandemic potential, as well as those addressing antimicrobial resistance (AMR) in the foreseeable future.

This material is intended to support other researchers to better understand the design and methodologies of proposed and existing studies, and to accelerate research planning by providing examples that may, where suitable, be adapted for other contexts.

If you would like to list your study on the coalition’s website, please contact us at info@cerclecoalition.org.

Study nameStudy typeAdditional detailsTreatment (if applicable)Study region(s)
ANTICOVRCT Phase III
Treatment of mild and moderate patients
Drug combination nitazoxanide + ciclesonideLow-resource settings
ATOMIC2RCT Phase II/IIITreatment of moderate patients
Azithromycin
UK
CAPE CODRCT Phase IIITreatment of critical patients
Hydroxycortisone
France
CLOVID-BHRCT Phase IibTreatment of severe patients
Chloroquine
Brazil
CODEXRCT Phase IIITreatment of critical patients
Hydroxycortisone
Brazil
COPCOVRCT Phase III
Pre-exposure prophylaxisHydroxychloroquine, chloroquine
Africa, Asia, Europe
COVEPIGUiPopulation survey
SeroprevalenceN/A
Guinea
COVID-19 PEPRCT Phase III
Post-exposure prophylaxis
Hydroxychloroquine
North America
CRASH-19RCT Phase III
Treatment of hospitalised patients
Aspirin, losartan, simvastatin
Pakistan, Nigeria
CRITICAL COVID-19Cohort study
Clinical outcomes of critical patients
N/A
Multiple
DISCOVERYRCT Phase III
Treatment of severe & critical patients
Remdesivir, lopinavir/ritonavir, interferon beta 1-A, hydroxychloroquine
Europe
ModernaRCT Phase IIIVaccine trialmRNA-1273 vaccine
USA
PERICOVIDCohort study
Mother-to-child transmission
N/A
UK
PRIORITISEObservational Triage of patients in low-resource settingsN/AIndia, Brazil, seeking others 
RECOVERYRCT Phase III
Treatment of hospitalised patients
Lopinavir/ritonavir, dexamethasone, hydroxychloroquine, azithromycin, convalescent plasma, tocilizumab
UK
REMAP CAPRCT Phase III
Adaptative trial platform
N/AN/A
RemdesivirRCT Phase III
Treatment of moderate hospitalised patients
Remdesivir
Multiple
SEBCOVObservational, mixed methods
Survey and qualitative research
N/A
Thailand, Malaysia, Italy, Slovenia, UK
PLATCOVopen-label RCT Phase II Treatment of early symptomatic COVID-19 patients Drugs with potential SARS-CoV-2 antiviral activity of three general typesThailand, Brazil, Pakistan, Laos, seeking others
VICORCT Phase IIb
Treatment of hospitalised patients
ChloroquineVietnam

Disclaimer
Note that study-related documents posted on the Coalition for Equitable ResearCh in Low-resource sEttings (CERCLE) website have been shared by members for information. Some may have been approved by Ethics Review Boards and others may still be in draft form. Documents posted here may have been further amended before being used in the conduct of the respective trials they were designed for. It is recommended that users review these documents carefully and, if they plan to use them, adapt them appropriately for their intended use. CERCLE and its members cannot accept any liability for any claim, loss or damages as a result of any reliance placed on, or use of, these documents.

Join CERCLE
We are looking for dedicated individuals and institutions who are eager to contribute their expertise and commitment to fast-track research in infectious diseases with potential for epidemics and pandemics, as well as antimicrobial resistance (AMR), specific to low-resource settings.